Plant-based Extracts Have Anti-inflammatory Effect on Piglets

Plant-based Extracts Have Anti-inflammatory Effect on Piglets

Researchers review plant-based feed additives for piglets fighting against PRRS or e. coli

Researchers at the University of Illinois are taking a closer look at the effects of plant-based extracts when fed to piglets trying to fight off porcine reproductive and respiratory syndrome and e. coli infections.

The two issues continue to be industry-wide problems that are costly.

"Either disease can sweep through a farm so their alleviation would substantially reduce production costs. Even though many management practices have been used in the swine industry, these practices cannot guarantee freedom from disease for pigs," says U of I researcher James Pettigrew.

ANTI-INFLAMMATORY EFFECTS: Researchers review plant-based feed additives for piglets fighting against PRRS or e. coli

To determine if plant extracts could combat either e.coli or PRRS, the researchers conducted two experiments. In both experiments, researchers used four diets in weanling pigs, including a control diet and three additional diets that included garlic botanical extracted from garlic, turmeric oleoresin extracted from ginger, or capsicum oleoresin from pepper.

In both experiments, half of the pigs in each dietary treatment were challenged with either E. coli or PRRS virus while the other half of the pigs were non-challenged.

"We've known for a long time that plant extracts, also called essential oils or botanicals, have certain biological actions," said Yanhong Liu, a doctoral student who led the studies. "For instance, they can act as antioxidants or as antimicrobials. We wanted to test whether we could get a benefit from feeding those products in very low doses to pigs that were challenged with these specific diseases."

Related: Moving Forward After PRRS Infection

The pigs in the study challenged with E. coli that had been fed any of the three plant extracts had a lower frequency of diarrhea (20%) than the pigs fed the control diet (40%). The pigs fed plant extracts were more efficient (40%) in feed use than the pigs fed the control diet in the E. coli-challenged group.

Liu noted that even the pigs in the non-challenged group, with a low frequency of mild diarrhea, benefited from the plant extracts. "Because there is a relatively high diarrhea rate in post-weaning pigs as they are moved from the mom and started on all solid feed, the extracts could also be used to reduce its occurrence," she said.


After feeding the pigs challenged with the PRRS virus the three plant extracts, the researchers observed that the pigs were more efficient in week 1 (55%) and week 2 (40%) than the pigs fed the control diet. The pigs continued eating and gaining weight. They found this to be especially true with turmeric, Liu said.

Inflammation reduction
When they checked blood samples from the pigs with the PRRS virus, they found that the pigs fed plant extracts also had a lower blood viral load (13%) and lower concentrations of inflammatory mediators than pigs fed the control diet.

These observations also suggest that feeding plant extracts could suppress ongoing inflammation and prevent secondary infections, researchers note. They believe the benefits resulted from the effects on the pigs' immune systems because feeding plant extracts reduced the inflammation caused by E. coli and the PRRS virus.

"In production animals, inflammation is costly. Inflammation reduces feed intake, and it diverts nutrients away from growth to the immune system," Pettigrew said. "If we can bring that quickly back down to normal after a challenge, then that helps in production."

Although previous studies have looked at using plant extracts in pig diets, Pettigrew said Liu's study, which looked at the effects of three different extracts on two different diseases, had not been done previously. He also added that the low concentration of the extracts used while still producing beneficial results set this study apart.

The researchers will continue to study the mechanisms behind the beneficial effects they observed, including conducting gene expression studies.

"We want to know the big picture of how these plant extracts affected the challenged and non-challenged pigs," Liu said.

View complete journal reports on the PRRS study and the e. coli study.

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